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Interolog Network Resource
Biological interaction networks are an increasingly important research tool for systems biology investigation. Many of the common model organisms such as Human, Fly, and Yeast, have good coverage of their interactome but other model organisms have limited coverage. To address the need for interaction data in other systems, methods have been developed to transfer interactions across species, and a few databases provide interaction lookup services for such data. Based on these methods, we have computed integrated interolog (interaction homolog) networks for each species represented in the NCBI HomoloGene database and have built Gaggle-enabled Cytoscape webstarts for immediate academic use.
Cytoscape WebStart Bundles for Model Organisms:
Notes:
When these start up, select "Trust" when prompted about the security clearence of the webstarts.
These are very large networks, so they take a while to load.
If there is an error with CyGoose or BioNetBuilder, try starting an instance of the
Gaggle Boss
before launching one of the webstarts.
* These networks are very large (> 10,000 nodes), so Cytoscape has no default visualization for them. To create one, go to "Edit" > "Create View". This will create a visualization for the network.
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Credit: Kevin Drew, Jay H. Konieczka, Iliana Avila-Campillo, Kevin Belasco, Alex Pine, John Lin, David J. Reiss, Richard Bonneau, Parker B. Antin
Brought to you by the Bonneau Lab at NYU and the Antin Lab at the
University of Arizona
Please sumbit any comments or questions to the BioNetBuilder disscussion group.
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